In this report, a framework is proposed to account for carbon uptake in Product Category Rules (PCRs) for creating EPDs. The proposed method elaborates the multi-level approach adopted to define carbon uptake estimation based on the information available to EPD producers and users. The report highlights the need for a probabilistic framework to account for uncertainties associated with the input data and modeling approach. The report also aims to provide guidelines for producers to incorporate carbon uptake estimates into EPDs based on end-use applications and create a baseline for a science-based and transparent method generalizable to other components of a CBP’s life cycle.